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UID:20250818T071930EDT-3246EdvGvv@132.216.98.100
DTSTAMP:20250818T111930Z
DESCRIPTION:Juan Helen Zhou presents\, 'Mapping multimodal brain network ch
 anges in neurological disorders: a longitudinal perspective'.\n\nRegistrat
 ion via Eventbrite.\n\nLivestreaming via vimeo.\n\nSpeaker:  Juan Helen Zh
 ou\, Ph.D.\n\nAssociate Professor\, Center for Sleep and Cognition & Deput
 y Director\, Center for Translational MR Research\, Yong Loo Lin School of
  Medicine\, National University of Singapore (NUS)\n\nAbstract:The spatial
  patterning of each neurodegenerative disease relates closely to a distinc
 t structural and functional network in the human brain. This talk will mai
 nly describe how brain network-sensitive neuroimaging methods such as rest
 ing-state fMRI and diffusion MRI can shed light on brain network dysfuncti
 ons associated with pathology and cognitive decline from preclinical to cl
 inical stage of neurological disorders. I will first present our findings 
 from two independent datasets on how amyloid and cerebrovascular pathology
  influence brain functional networks cross-sectionally and longitudinally 
 in individuals with mild cognitive impairment and dementia. Evidence on lo
 ngitudinal functional network organizational changes in healthy older adul
 ts and the influence of APOE genotype will be presented. In the second par
 t\, I will describe our work on how different pathology influences brain s
 tructural network and white matter microstructure. I will also touch on so
 me new data on how individual-level brain network integrity contributes to
  behavior and disease progression using multivariate computational approac
 hes. These findings underscore the importance of studying selective brain 
 network vulnerability instead of individual region and longitudinal design
 . Further developed with machine learning approaches\, multimodal network-
 specific imaging signatures will help reveal disease mechanisms and facili
 tate early detection\, prognosis and treatment search of neuropsychiatric 
 disorders.\n\nThe Feindel Virtual Brain and Mind (VBM) Seminar Series will
  advance the vision of Dr. William Feindel (1918–2014)\, Former Director o
 f the Neuro (1972–1984)\, to constantly bridge the clinical and research r
 ealms. The talks will highlight the latest advances and discoveries in neu
 ropsychology\, cognitive neuroscience\, and neuroimaging.\n\nSpeakers will
  include scientists from across The Neuro\, as well as colleagues and coll
 aborators locally and from around the world. The series is intended to pro
 vide a virtual forum for scientists and trainees to continue to foster int
 erdisciplinary exchanges on the mechanisms\, diagnosis and treatment of br
 ain and cognitive disorders.\n
DTSTART:20210317T130000Z
DTEND:20210317T140000Z
SUMMARY:Feindel Virtual Brain and Mind Lecture Series: Mapping multimodal b
 rain network changes in neurological disorders: a longitudinal perspective
URL:/neuro/channels/event/feindel-virtual-brain-and-mi
 nd-lecture-series-mapping-multimodal-brain-network-changes-neurological-32
 9383
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