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Major Partnerships

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The Major Partnerships funding program offers two distinct funding streams and flexibility to accommodate the versatile nature of interactions in the translational and commercialization space. The program supports co-funding of D2R researchers and associated projects with different types of partners by providing a 1:1 leverage or greater (depending on leveraging) for specific projects. The program accepts proposals at any time.

The review and selection process for the Major Partnerships program follows two stages:

  • Letter of Intent review: This initial step ensures that proposed projects are in alignment with D2R’s mission. Approved projects are invited to submit a full application.
  • Full application review: Projects proceed to detailed evaluation and external scientific merit review. D2R's Research Steering Committee reviews the reviewer evaluations, the project's relevance to D2R's strategic goals and the program budget in its funding decisions.

Major Partnerships Awards

Principal Investigator Title Partner(s)
Nicolas Moitessier Machine learning models for the design of »ÆÆ¬ÀóÖ¦ÊÓÆµ therapeutics: Development of experimental data Deep Genomics
Jörg Fritz Rapid antigen identification platform for vaccine development Médicament Québec, »ÆÆ¬ÀóÖ¦ÊÓÆµ Technologies and Therapeutics Inc., AReNA, NovoArc GmbH, Victor Phillip Dahdaleh Institute for Genomic Medicine
Masad Damha Therapeutic development of the CRISPR-Cas12a gene editing system Eli Lilly

Machine learning models for the design of »ÆÆ¬ÀóÖ¦ÊÓÆµ therapeutics: Development of experimental data

In partnership with Deep Genomics, this project aims to speed up the discovery of »ÆÆ¬ÀóÖ¦ÊÓÆµ-based medicines using artificial intelligence. By combining lab-generated data with computational models, the team will lay the foundation for machine learning tools that could transform how »ÆÆ¬ÀóÖ¦ÊÓÆµ therapies are developed.

Principal Investigator: Nicolas Moitessier (»ÆÆ¬ÀóÖ¦ÊÓÆµ)
Co-Investigator: Anthony Mittermaier (»ÆÆ¬ÀóÖ¦ÊÓÆµ)
Partner(s): Deep Genomics
Project duration: 18 months
Relevant D2R Axes: »ÆÆ¬ÀóÖ¦ÊÓÆµ Therapeutics (Axis 2)

Rapid antigen identification platform for vaccine development

Announced at BIO International 2025, this project, co-funded by Médicament Québec, »ÆÆ¬ÀóÖ¦ÊÓÆµ Technologies and Therapeutics Inc., AReNA, NovoArc GmbH and the Victor Phillip Dahdaleh Institute, represents a major collaborative effort in the development of next-generation m»ÆÆ¬ÀóÖ¦ÊÓÆµ vaccines. The project will build a rapid preclinical platform to identify vaccine targets and test new m»ÆÆ¬ÀóÖ¦ÊÓÆµ vaccine technologies, enabling researchers to respond faster and more effectively to emerging infectious diseases. The project involves collaborations with academic and industry partners to validate the platform’s utility in real-world scenarios.

Principal Investigator: Jörg Fritz (»ÆÆ¬ÀóÖ¦ÊÓÆµ)
Co-Investigators: Silvia Vidal (»ÆÆ¬ÀóÖ¦ÊÓÆµ), David Langlais (»ÆÆ¬ÀóÖ¦ÊÓÆµ)
Collaborators: David J. Kelvin (Dalhousie University), Alyson A. Kelvin (University of Calgary), Mohamad-Gabriel Alameh (»ÆÆ¬ÀóÖ¦ÊÓÆµ Technologies and Therapeutics), David Wurm (NovoArc GmbH)
Partners: Médicament Québec, »ÆÆ¬ÀóÖ¦ÊÓÆµ Technologies and Therapeutics Inc., AReNA, NovoArc GmbH, Victor Phillip Dahdaleh Institute for Genomic Medicine
Project duration: 26 months
Relevant D2R Axes: »ÆÆ¬ÀóÖ¦ÊÓÆµ Therapeutics (Axis 2)

Therapeutic development of the CRISPR-Cas12a gene editing system

This collaborative project between McGill, Eli Lilly and Wake Forest University involves nucleic acid chemistry and biology and student training aimed at enhancing the drug-like properties of »ÆÆ¬ÀóÖ¦ÊÓÆµ therapeutics. This project will build on chemical design principles, establish a »ÆÆ¬ÀóÖ¦ÊÓÆµ modification platform, and accelerate the development of CRISPR-Cas12a as a human gene therapy for curing genetic disorders.

Principal Investigator: Masad Damha (»ÆÆ¬ÀóÖ¦ÊÓÆµ)
Partner(s): Eli Lilly & Company
Collaborator(s): Gagnon Keith (Wake Forest University Medical Center)
Project duration: Two-years
Relevant D2R Axes: »ÆÆ¬ÀóÖ¦ÊÓÆµ Therapeutics (Axis 2)

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