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Claudia Kleinman

Claudia Kleinman

Assistant Professor Human Genetics
E-mail: claudia.kleinman [at] mcgill.ca

Research Area: Genomics & Bioinformatics; Computational Biology

Through the computational analysis of genome-wide data, we try to elucidate mechanisms regulating transcription and »ÆÆ¬ÀóÖ¦ÊÓÆµ processing, their interplay with genetic and epigenetic factors, and how they cause disease. We focus on cancer and brain development, two areas where deregulated gene expression plays a major role, and where unprecedented amounts of data are being produced. We combine genomic technologies with computational approaches to analyze, for example, the dynamics of »ÆÆ¬ÀóÖ¦ÊÓÆµ processing in the developing human brain, or how transcription at the single cell level can be used to resolve cell-to-cell variation and to identify rare cells driving disease progression and therapeutic resistance.

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