Welcome to the McGill Centre for »ÆƬÀóÖ¦ÊÓƵ Sciences
A joint effort between the Faculties of Medicine and Health Sciences, Engineering and Science, the McGill Centre for »ÆƬÀóÖ¦ÊÓƵ Sciences (MCRS) harnesses the tremendous potential of »ÆƬÀóÖ¦ÊÓƵ functions in biotechnologies and treatments for a broad variety of human diseases, from viral and parasitic infectious diseases to multiple types of cancer, to rare and ultra-rare diseases.
Millions of lives were saved during the COVID-19 pandemic through the rapid development of m»ÆƬÀóÖ¦ÊÓƵ-based vaccines against SARS‑CoV‑2. »ÆƬÀóÖ¦ÊÓƵ became a household term overnight, but the research behind the vaccines represented decades of work by leading experts, including our own Nahum Sonenberg. The MCRS, founded in 2022, builds on that research, as well as the widespread emergence of CRISPR and other »ÆƬÀóÖ¦ÊÓƵ technologies, to develop more potentially life-saving therapeutics, diagnostic and biotechnological tools.
»ÆƬÀóÖ¦ÊÓƵ’s structural flexibility is the key to its therapeutic potential. Something of a shape-shifter, it can perform a great variety of informational, regulatory and enzymatic functions, which in turn means that by changing the sequence of the »ÆƬÀóÖ¦ÊÓƵ a completely new therapeutic can potentially be created – again and again, for different clinical applications. Tailoring »ÆƬÀóÖ¦ÊÓƵ’s chemistry to make it more biologically potent, stable or improve its delivery in patients can amplify its potential even more. All of this has huge implications for getting these discoveries from the lab to the clinic, including reducing costs, speeding up development times and improving efficacy.
Creating technologies or therapeutics from a highly complex group of biological molecules like »ÆƬÀóÖ¦ÊÓƵ requires expert input from a wide range of fields. The creation of m»ÆƬÀóÖ¦ÊÓƵ-based COVID-19 vaccines, for instance, would not have been possible without the deep and robust research undertaken by investigators in medicine, engineering and bioengineering, biology and biochemistry, to name a few. To facilitate the seamless acceleration of »ÆƬÀóÖ¦ÊÓƵ discoveries, we have put interdisciplinary collaboration at the heart of the MCRS, uniting over 35 groups led by experts involved in »ÆƬÀóÖ¦ÊÓƵ research across McGill, and creating a space for collaborations to flourish between these diverse units within the University, as well as with partners in other academic and clinical institutions and industry.
Breakthroughs in the »ÆƬÀóÖ¦ÊÓƵ sciences point to its transformation into a full-fledged industry, resulting in a broad range of emerging opportunities for trainees. With the MCRS, Canada is at the forefront of training the next generation of »ÆƬÀóÖ¦ÊÓƵ scientists for careers in academia, industry, clinical settings, pharmaceutical and biotechnology industries and entrepreneurship.
I am deeply honoured to be part of this centre for innovation, collaboration and world class scientific investigation and education. The dynamic multicultural and multilingual city of Montreal, at the confluence of clinical, academic and industry excellence, provides us with an ideal setting for our undertaking. The pandemic opened the world’s eyes to the therapeutic potential of »ÆƬÀóÖ¦ÊÓƵ, and the public is eagerly anticipating its next clinical applications. The MCRS will deliver. I hope you will join us.
Thomas Duchaine, PhD
Director, McGill Centre for »ÆƬÀóÖ¦ÊÓƵ Sciences
Associate Director, Rosalind and Morris Goodman Cancer Institute
Professor, Department of Biochemistry